اثر ان- استیل سیستئین بر میزان عامل نکروز تومور آلفا در توده سیاه و جسم مخطط مغز در مدل پارکینسونی موش صحرایی

Background and purpose: Accumulated evidences indicate that the inflammatory pathways have an important role in both the initiation and progression of Parkinson’s disease. On the other hand the anti-inflammatory properties of N-acetylcysteine (NAC) have been proven in many studies. Therefore, this study aimed to evaluate the effect of NAC on motor symptoms and TNF-α level of substantia nigra and striatum in animal model of Parkinson’s disease. Materials and methods: In order to induce Parkinson’s disease model, male Wistar rats weighting 400±50g (10-12 months) received rotenone (2.5 mg/kg/48h sc) for 20 days. Pretreatment with NAC (25 and 50 mg/kg/48h ip) was administered one hour before the rotenone injection. For behavioral assessment, rotarod test was run in order to measure motor symptoms and certifying the model. The TNF- α level in substantia nigra and striatum region of brain was determined using ELISA technique. Results: The results showed that N-acetylcysteine prevented both failure of motor performance and increasing of TNF-α level. Conclusion: This study found that N-acetylcysteine prevented the development of rotenone model of Parkinson’s disease. This effect might be related to the anti-inflammatory characteristics of Nacetylcysteine.